منابع مشابه
O 13: Ion Channels in Autoimmune Neurodegeneration
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
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pAper type 290 Channels Volume 8 Issue 4 AutoCommentAry A decrease in arterial O 2 pressure (pO 2) elicits a peripheral chemosensory reflex that increases ventilation and sympathetic nerve activity. This reflex is initiated at the carotid body glomus (Type 1) cells where the reduced pO 2 alters the activities of various ion channels and causes cell depolarization. The depolarization opens the v...
متن کاملImaging Large Cohorts of Single Ion Channels and Their Activity
As calcium is the most important signaling molecule in neurons and secretory cells, amongst many other cell types, it follows that an understanding of calcium channels and their regulation of exocytosis is of vital importance. Calcium imaging using calcium dyes such as Fluo3, or FRET-based dyes that have been used widely has provided invaluable information, which combined with modeling has esti...
متن کاملo 13: ion channels in autoimmune neurodegeneration
multiple sclerosis (ms) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. ionic conductances regulate t cell activation as well as neuronal function and thus have been found to play a crucial role in ms pathogenesis. since present therapeutical approaches are only parti...
متن کاملIon Channels
Ion channels catalyze the transmembrane movement of small inorganic ions across biological membranes. They do so by forming continuous, hydrophilic pores through which ions can cross the barrier imposed by the lipid bilayer hydrophobic core. Ion channels serve many functions: they underlie the changes in membrane potential that control many cell functions, including the propagated electrical si...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2021
ISSN: 0003-2700,1520-6882
DOI: 10.1021/acs.analchem.1c00224